摘要
目的总结中国小型猪非转流条件下原位肝移植的围手术期特点,建立成熟、稳定的移植模型。方法通过预实验组8例次和实验组18例次非转流条件下中国小型版纳猪原位肝移植术,观察围手术期血流动力学及重要代谢指标的变化,改进围手术期处理措施,总结围手术期处理特点。结果预实验组8例次均在术后当天死亡。实验组18例次无术中死亡,术后7天存活率为88.9%。平均手术时间(179.6±14.3)min,平均无肝期(27.3±3.4)min。无肝期血流动力学及生化代谢波动明显。术后当天麻醉清醒,术后3～5h开始自行排出小便,术后第三天正常进食。结论无肝期手术时间的缩短及血流动力学的相对稳定是非转流条件下猪原位肝移植成功的关键。
Objective To summarize the feature of perioperative management in the orthotopic liver transplantations (OLTs) in miniature porcine, and to establish the matural and stable models. Methods 8pous preliminary experiments and 18pous experiments of OLTs were performed without veno-venous bypass (VVB) in Chinese inbred miniature porcine in order to observe hemodynamics and blood changes, and improve perioperative management. Result The mean operation time was (179.6±14.3)min, and the mean anhepatic phase time was(27.3±3.4)min in our 18 OLTs. Dramatic hemodynamic and metabolism changes were identified during anhepatic phase. The one-week survival rate was 88.9%. Experiment group discarded urine after 3～5 hours and had normal eating after 3 days. Conclusion Decreasing the operation time and stability of hemodynamics in anhepatic phase is the key problem in OLTs without VVB.
出处
《中华普通外科学文献（电子版）》
2007年第1期17-19,共3页
Chinese Archives of General Surgery(Electronic Edition)
基金
广东省科技计划项目(2004B35001009)
关键词
原位肝移植
外科技术
围手术期处理
中国小型版纳猪
Orthotopic liver transplantation
Surgical technique
Perioperative management
Inbred miniature porcine
