摘要
目的探讨嗜麦芽寡养食单胞菌肺部感染的现状及对策。方法嗜麦芽寡养食单胞菌肺部感染患者临床表现、X光影像及实验室资料48例,呼吸道分泌物标本用常规方法分离培养,并进行菌种鉴定及药敏测定。结果嗜麦芽寡养食单胞菌肺部感染的临床表现无特征性,绝大多数为医院内感染(45/48)占93.7%。易感因素有:长期大量经验性使用广谱抗生素,免疫抑制剂及化疗药物的使用,机械通气及侵入性操作,年老、免疫功能低下及住院时间长等。嗜麦芽寡养食单胞菌耐药机制复杂,对多种常用抗生素耐药,处理不当可导致ICU内易感人群中流行。结论减少易感因素,早作病原学检查,针对性联合应用TMP-SMZ头孢派酮/舒巴坦或左旋氧氟沙星等,可提高该菌的清除率。
Objective To study the situation of pulmonary infection caused by stenotrophomonas maltophilia . Methods The clinical data of 48 cases pulmonary infection caused by stenotrophomonas maltophilia , including clinical menifestation , X-ray imagine and lab data, was collected. Bacterial culture of respiratory sample, species identification of bacteria and drug sensitivity test was made. Results The clinical menifestation caused by stenotrophomonas maltophilia had no characteristic symptom. Most cases were hospital infection(45/48).The risk factors included long term , large dose using of broad-spectrum antibiotics, using immune inhibitor and chemical therapeutic drugs, mechanical ventilation, invasive operation,old, lower immunosystem function and long term in-hospital. The mechanism of drug resistance of stenotrophomonas maltophilia was complicated. Stenotrophomonas maltophilia showed resistance to many broad-spectrum antibiotics.Conclusion Avoiding risk factor, early pathogen identification , combination using TMP-SMZ and Ticarcillin/clavalanic or levefloxacin can improve the clearance rate of the bacteria.
出处
《中国实用医药》
2007年第15期94-96,共3页
China Practical Medicine
关键词
嗜麦芽寡养食单胞菌
肺部感染
易感因素
耐药
Stenotrophomonas maltophilia
Risk factor , Pulmonary infection
Drug resistance
