摘要
目的 :测定肺部感染患者静脉注射替硝唑的药物动力学。方法 :采用反相高效液相色谱法测定血清中替硝唑的浓度 ,以甲硝唑为内标 ,水 -乙腈 -醋酸 (80∶2 0∶0 1 )为流动相 ,在 1～ 5 0mg/L范围内线性关系良好 ,最低检测限 0 1mg/L。 7名住院肺部感染患者静脉滴注替硝唑葡萄糖注射液40 0mg ,90min内滴完。于滴注前和滴注后取患者对侧上肢静脉血 2ml测定。结果 :药 -时曲线符合二室开放模型 ,有关药动学参数分别为T1 / 2α=(2 42± 1 75 )h ,T1 / 2 β=(1 4 2 0± 4 0 0 )h ,AUC0～∞ =(2 1 9 0± 83 9)mg.h/L ,Vc=(2 6 5 8± 1 1 75 )L。结论
OBJECTIVE:To determine pharmacokinetics of tinidazole in patients with lung infection.METHODS:The concentration of tinidazole in patients serum was determined by a RP-HPLC method.Metronidazole was being internal standard and a mobile phase of wateracetonitrile-acetic acid(80∶20∶0 1) were used.There was a good liner relation within the range of 1～50mg/L and the determination limit was 0 1mg/L.Of these patients,5 males and 2 females,were driped intravenously 400mg of tinidazole within 90min.RESULTS:The res...
出处
《药学实践杂志》
CAS
2000年第6期372-374,共3页
Journal of Pharmaceutical Practice
