摘要
对近年来蜘蛛肽类神经毒素结构与功能研究的新进展作了概述 .在蜘蛛毒液中发现含有丰富的肽类神经毒素 .至今已有近 10 0种蜘蛛神经毒素的一级结构被测定 ,除黑寡妇蜘蛛毒素为高分子量毒素外 ,其它蜘蛛神经毒素的相对分子质量在 3× 10 3～ 12× 10 3之间 ,不同种属来源的毒素同源性很小 ,序列中含有较多的半胱氨酸 .这些毒素功能多样 ,可与细胞膜上的Na+ 、K+ 或Ca2 + 等离子通道相互作用 .由于它们对离子通道的选择性 ,这些毒素在神经生物学和药理学研究上已得到了广泛的应用 .
Spider venom contains a variety of neurotoxic peptide components. The amino acid sequences of about 100 kinds of spider toxin have been determined so far. Their molecular weights were varied from 3×10 3 to 12×10 3 except for black widow spider toxins, which were high molecular mass types. There were plenty of cysteine residues in their sequences. Toxins from different genus share less sequence homology. They can interact with varying kinds of ion channels such as Na +,K + and Ca 2+ . For their selec...
出处
《生命科学研究》
CAS
CSCD
2000年第S1期1-9,共9页
Life Science Research
基金
国家 8 6 3项目资助! (10 3 13 0 1 0 6 )
关键词
蜘蛛
神经毒素
多肽
一级结构
离子通道
spider
neurotoxin
peptide
amino acid sequence
ion channel
