摘要
目的探讨血清与脑脊液S100B含量与吉兰-巴雷综合征(Guillain-Barr syndrome,GBS)不同亚型及病程的关系。方法选取31例吉兰-巴雷综合征患者,其中包括经典吉兰-巴雷综合征(acute inflammato-ry demyelinative polyradicul-oneuropathy,AIDP)患者18例,急性运动轴索型神经病(acute motor axon neuropathy,AMAN)患者13例,对照组血清30例,对照组脑脊液10例,用ELISA法测定其S100B的含量;对GBS患者进行1年随访,评价S100B与GBS病程的关系。结果血清S100B含量AIDP组明显高于AMAN组(P<0.05)和对照组(P<0.05),AMAN组与对照组比较无明显差异(P>0.05);而在脑脊液中S100B含量AIDP组明显高于AMAN组和对照组(P<0.05),AMAN组和对照组间亦有明显差别(P<0.05);两组GBS患者脑脊液S100B含量均高于其同组的血清S100B含量(P<0.05);AIDP组血清和脑脊液S100B含量与患者病初运动功能缺失程度(初次Hughes评分)相关,前者r=0.9155,后者r=0.5716。AMAN组血清和脑脊液S100B含量与患者病初运动功能缺失程度(初次Hughes评分)均有相关性,前者r=0.7789,后者r=0.8607。AIDP组血清和脑脊液S100B含量与患者病程一年运动功能恢复程度(末次Hughes评分)都有相关性,前者r=0.7690,后者r=0.6448。AMAN组血清和脑脊液S100B含量与患者病程一年运动功能恢复程度(末次Hughes评分)均有相关性,前者r=0.8677,后者r=0.8651。结论测定血清和脑脊液S100B含量对指导分型具有一定的临床意义,而用血清和脑脊液S100B含量的高低预测GBS病程则不可取,但是如能在结合病理和电生理等检查基础上确定GBS的分型后,血清和脑脊液S100B含量血清和脑脊液S100B含量的高低在一定程度上可以预测患者的病程。
Objective To investigate the relation between the concentration of serum and CSF S100B and different types,and courses in GBS. Methods The concentration of S100B was measured by ELISA from the serum of 31 GBS patients including 18 AIDP and 13 AMAN,30 Serum references、10 CSF references.The time for investing the state of patients was one year for deciding the relation between the concentration of S100B and the courses. Results The concentration of serum S100B inAIDP groups was higher than it in AMAN and cont...
出处
《脑与神经疾病杂志》
2009年第1期47-51,共5页
Journal of Brain and Nervous Diseases
基金
河北省卫生厅科技攻关课题(03036)
