摘要
目的:通过检测血清一氧化氮(NO),诱导型一氧化氮合成酶(iNOS)及超氧化物歧化酶(SOD)水平,研究酪酪肽(PYY)对重症急性胰腺炎大鼠的作用。方法:健康雄性SD大鼠40只,体重250～300g。随机分成胰腺炎组(20只)和治疗组(20只)两组,实验前大鼠禁食12h,自由饮水。两组大鼠均分3次腹腔内注射6%l-精氨酸溶液(3×1.5mg/g),中间间隔1h。治疗组大鼠在第1次腹腔内注射精氨酸后立即皮下注射酪酪肽(0.8pmol/g体重),此后每间隔4h皮下注射1次,共注射10次。将实验大鼠分别在造模后48h作血清NO,iNOS及SOD测定。结果:酪酪肽治疗组血清NO及iNOS明显低于重症急性胰腺炎组,而血清SOD明显高于重症急性胰腺炎组。结论:酪酪肽对重症急性胰腺炎的保护治疗作用可能与降低血清NO含量,抑制iNOS活性,提高SOD活性有关。
Objects:To investigate the effects of Peptide YY(PYY)on severe acute pancreatitis(SAP)in rats by detecting serum nitric oxide(NO),inducible nitric oxide synthase(iNOS)and Superoxide Dismutase(SOD).Methods:40 rats were randomly divided into two groups:acute pancreatitis group(SAP group n = 20)and treatment control group(SAP+PYY group n = 20).SAP model was established by intraperitoneal injection of 60g/L L-Arginine.Rats in two groups were injected intraperitoneally with 60g/L L-Arginine(3×1.5 mg/g)three time...
出处
《陕西医学杂志》
CAS
北大核心
2008年第11期1466-1468,共3页
Shaanxi Medical Journal
