摘要
目的观察NMP238、HSP70在放疗敏感性不同宫颈癌组织中的表达及意义。方法收集治疗前宫颈癌组织标本,病理诊断均为中分化鳞癌,在进行放疗后,根据WHO实体瘤放疗疗效判断标准,从中选择36例对放疗敏感的病例(高敏感组)和24例对放疗不敏感的病例(低敏感组),应用免疫组化方法检测组织中这些蛋白的表达。结果60例宫颈鳞状细胞癌患者放疗后CR:36例,占60.0%(36/60)。PR:22例,占36.7%(22/60);NC:2例,占3.3%(2/60);PD:0例。免疫组化结果显示NMP238,HSP70的阳性表达率在高敏感组中均低于低敏感组。结论NMP238、HSP70表达与宫颈癌放疗敏感性有关。NMP238与HSP70的表达状态可能作为预测宫颈鳞状细胞癌放疗敏感性的指标。
ObjectiveTo investigate the association of the expression of NMP238 and HSP70 in pre-radiotherapy tissues with the radiation therapy sensitivity in human cervical squamous cell carcinoma. Methods60 samples from patients with pathologically diagnosed as cervical squamous cancer were collected. These 60 cervical squamous cancer samples were divided into two groups according to the response to RT as radiosensitive(CR) and radioresistant groups(PR+NC+PD) . Immunohistochemical experiments were performed to detec...
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2008年第23期3503-3506,共4页
China Journal of Modern Medicine
基金
湖南省科技计划项目(No:2007SK3010)
关键词
NMP238
HSP70
宫颈鳞状细胞癌
免疫组化
nuclear matrix protein 238
heat shock protein 70
cervical squamous cancer
immuohistochemistry
