摘要
目的:探讨正常和妊娠期肝内胆汁淤积症(ICP)胎盘组织中核因子-κB(NF-κB)表达的意义。方法:采用组织微阵列技术和免疫组织化学染色方法检测正常胎盘(30例)和ICP胎盘(轻度28例,重度19例)组织中NF-κB p65蛋白的表达水平。结果:NF-κB p65在正常胎盘和ICP胎盘绒毛表面合体滋养细胞胞浆和胞核内呈阳性表达,绒毛间质的血管平滑肌和内皮细胞内表达较少;ICP重度组单位胎盘面积IOD最高(95.69±13.49),ICP轻度组次之(71.37±7.74),正常胎盘最低(57.54±4.13),三组间差异显著(P<0.01)。结论:ICP胎盘组织NF-κB表达明显增高,且与ICP的疾病程度有关,NF-κB激活与ICP发生发展过程有关。
Objective:To explore the expression of nuclear factor kappa B(NF-κB) in placenta of normal pregnancy and intrahepatic cholestasis of pregnancy(ICP) and to analyze the clinical significance.Methods: Forty-seven ICP patients were graded into mild ICP group(n=28,TBA<40 μmol/L) and severe ICP group(n=19,TBA≥40 μmol/L) based on serum total bile acid(TBA) level.The expression of NF-κB p65 protein in normal(n=30,control group) and ICP placenta was determined by immunohistochemistry combined with tissue microarr...
出处
《西北国防医学杂志》
CAS
2008年第6期438-441,共4页
Medical Journal of National Defending Forces in Northwest China
关键词
妊娠期肝内胆汁淤积症
胎盘
核因子-ΚB
Intrahepatic cholestasis of pregnancy
Placenta
Nuclear factor kappa B
