摘要
目的:观察老年大鼠心肌PPARβ/δmRNA和MMP-9 mRNA表达情况及阿托伐他汀的影响。方法:30只20月龄Wister鼠,分为老年对照、大剂量和小剂量阿托伐他汀组。10只3月龄大鼠为青年对照。用RT-PCR检测大鼠心肌PPARβ/δmRNA和MMP-9 mRNA表达水平。结果:①老年大鼠PPARβ/δmRNA表达水平较青年组显著降低(P<0.01),阿托伐他汀可显著上调其表达(P<0.01);②老年大鼠MMP-9 mRNA表达水平较青年组显著增高(P<0.01),阿托伐他汀显著抑制其表达(P<0.01);结论:阿托伐他汀显著抑制老年大鼠心肌MMP-9 mRNA的表达,PPARβ/δ可能参与了这一过程。
Objective:To explore the effect of atorvastatin on the expressions of PPAR β/δ mRNA and MMP-9 mRNA in myocardium of aging rats.Methods: Thirty 20-month Wistar rats were divided into aging control group,high-dose atorvastatin group and low-dose atorvastatin group,and ten 3-month Wistar rats as young control group.The expressions of PPAR β/δ mRNA and MMP-9 mRNA were detected by RT-PCR.Results:The expression of PPAR β/δ mRNA in aging rats was significantly lower than that of young rats(P<0.01),and atorvasta...
出处
《西北国防医学杂志》
CAS
2008年第6期412-414,共3页
Medical Journal of National Defending Forces in Northwest China
基金
北京市自然科学基金资助项目(7082083)
