摘要
目的:比较虎杖与氨力农对急性缺氧性肺动脉高压动物模型血流动力学、纤溶系统及肺功能的作用。方法:观察静脉注射虎杖、氨力农注射液对急性缺氧性猪血流动力学、血中纤溶系统及肺功能指标的影响,并进行比较。结果:虎杖和氨力农组肺动脉压与用药前比较均显著下降(P<0.01),心搏指数有所增加,但差异无显著性(P>0.05)。组织型纤溶酶原激活剂含量(t-PA)虎杖组用药后较用药前显著增加(P<0.05),氨力农组用药后变化不明显(P>0.05)。血浆纤溶酶原激活剂抑制物含量(PAI)虎杖组用药后较用药前有所下降,但差异无显著性(P>0.05),氨力农组变化不明显(P>0.05)。虎杖组肺顺应性有所增加,呼吸功有所下降,氨力农组变化不明显。结论:虎杖和氨力农均可明显降低缺氧引起的肺动脉高压,有增加心输出量趋势。虎杖能部分增强纤溶系统活性,并有增加肺的顺应性,减少呼吸功趋势。
Objective:To investigate comparatively the effect of Polygonum cuspidatum(PC)and amrinone on hemodynamics,fibrinolysis sys- tem and pulmonary function in pigs with acute hypoxic pulmonary hypertension.Methods:Indices of hemodynamics,pulmonary function and blood fibrinolysis were observed before and after intravenous injection of PC and compared with those after amrinone treatment.Re- suits:In both groups after treatment,pulmonary arterial pressure lowerec significantly(P<0.01 ),cardiac index increased wi...
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
2002年第S1期95-97,共4页
Chinese Journal of Integrated Traditional and Western Medicine
基金
上海市科学技术发展基金课题(No.98(B)302)
关键词
虎杖
氨力农
缺血性肺动脉高压
动物模型
心输出量
Polygonum cuspidatum
amrinone
hypoxic pulmonary hypertension
animal model
cardiac output
