摘要
目的:观察构杞多糖(LBP)对酒精性肝病的作用。方法:采用饮用酒精饮料(酒精浓度从5%递增至40%,终浓度为40%,共计29周)复制酒精性肝病模型,25周时存活的大鼠随机分为模型组、两个不同剂量 LBP 防治组(250 mg/kg 体重和1000 mg/kg 体重)。检查血清酶学、血脂、肝内脂质、脂质过氧化并观察光镜下的肝脏形态学改变。结果:与模型组比较,LBP 防治组血清转氨酶下降、LDL-C 下降;肝内甘油三酯、总胆固醇减低;肝内超氧化物歧化酶(SOD)活力和γ-谷氨酰半胱氨酸甘氨酸(GSH)含量升高、丙二醛(MDA)下降;肝脏形态学明显改善。大剂量效果更优。血清甘油三酯(TG)呈下降趋势,但无统计学意义。结论:构杞多糖对酒精性肝病具有一定的防治作用。
Objective:To observe the effect of Lycium Barbarum polysaccharide(LBP)on alcoholic liver disease(ALD).Methods:Rat ALD model was formed by feeding alcoholic beverage with concentration of alcohol increased gradually from 5% to 40% for 29 weeks.Those survived in 25 weeks were randomly divided into the model group and the two LBP groups treated with low and high dose of LBP(250 mg/kg and 1000 mg/kg).Changes of enzymes and lipids in blood,lipid and lipid peroxide in liver,and microscopic morphological changes o...
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
2002年第S1期141-143,共4页
Chinese Journal of Integrated Traditional and Western Medicine
关键词
枸杞多糖
酒精性肝病
大鼠
病理学
血清学
脂质过氧化
Lycium barbarum polysaccharide
alcoholic liver disease
rat
pathology
serology
lipid peroxidation
