摘要
目的 :探讨小睾丸组织超微结构变化和性激素改变及其相关性。 方法 :对 8例小睾丸病人和 12例健康成人血清进行性激素测定 ,光镜及电镜观察小睾丸组织的超微结构变化。 结果 :小睾丸病人和正常对照组血清性激素FSH、LH、T分别为 (2 1.0 5± 9.15 )IU/Lvs (6 74± 3 5 2 )IU/L、(2 2 .88± 6 .2 5 )IU/Lvs (6 6 0± 1 4 8)IU/L、(0 .30± 0 .0 4 )nmol/Lvs (17 5 5± 9 2 5 )nmol/L ,两者相比差异有显著性 (P <0 .0 1) ;精曲小管直径和管壁厚度分别为 (37.33± 6 .80 )、(10 .30± 1.82 ) μm ,与正常组的 (198 4 6± 2 9 84 )、(2 95± 0 2 0 ) μm相比 ,差异有极显著性 (P <0 .0 1) ;组织超微结构变化显著。 结论 :小睾丸组织精曲小管、生精上皮、支持细胞、界膜、间质细胞及血管均发生严重的病理改变 。
Objectives: To investigate the tissue ultrastructure changes of small testis and sex hormone and their correlation. Methods: The patients were divided into small testis ( n =8)and control group( n =12). FSH, LH, T were determined by radioimmunassay. Diameter and wall thickness of convoluted seminiferous tubule were investigated with light microscope and electro microscopy on small testis tissue morphology and ultrastructure. Results: FSH, LH , T of small testis and control group were ( 21.05 ± 9.15 ) IU/L vs (6 74±3 52) IU/L, ( 22.88 ± 6.25 ) IU/L vs (6 60±1 48) IU/L and (0.30±0.04) nmol/L vs (17 55±9 25) nmol/L, respectively. Seminiferous tubule diameter and wall thickness were( 37.33 ± 6.80 ) μm vs (198 46±29 84) μm and ( 10.30 ± 1.82 ) μm vs (2 95±0 20) μm. Small testis tissue ultrastructure changed significantly. Conclusions: Pathologic changes of small testis tissue in many parts such as seminiferous tubule, germinal epithelium, Sertoli cell, Leydig cell, limiting membrance and blood vessel may relate with genetics and immunoreaction.
出处
《中华男科学杂志》
CAS
CSCD
2002年第3期186-189,共4页
National Journal of Andrology
关键词
小睾丸
超微结构
性激素
Small testis
Ultrastructure
Sex hormone
