摘要
目的 探讨黄芪在肾缺血再灌注损伤中对细胞粘附分子 1(ICAM 1)表达的影响。方法 将实验大鼠随机分为正常组、缺血再灌注组和黄芪治疗组。应用病理免疫组织化学方法 ,分别检测大鼠正常、肾缺血1h、再灌注 2 4、48、72、96h时肾小球内ICAM 1的表达。结果 正常组大鼠肾小球内未见ICAM 1表达。缺血再灌注组和黄芪治疗组再灌注 2 4h大鼠肾小球内ICAM 1明显表达 ,48、72h达高峰 ,96h回落。与缺血再灌注组比较 ,黄芪治疗组大鼠肾小球内ICAM 1表达受到显著抑制 (P <0 .0 1)。结论 黄芪在肾缺血再灌注损伤过程中 ,减轻肾内炎症细胞浸润的作用较慢 。
Objective To investigate the effect of Astragalus on expression of intercellular adhesive molecule 1 (ICAM 1) in renal ischemia reperfusion injury. Methods The rats were divided into three groups: normal control, renal ischemia reperfusion model and Astragalus treated groups. Astragalus was injected intraperitoneally daily two weeks before onset of renal ischemia reperfusion. Ater 1 h renal ischemia and 24 h, 48 h, 72 h and 96 h, after reperfusion the glomerular ICAM 1 expression was detected by im...
出处
《上海医学》
CAS
CSCD
北大核心
2003年第S1期55-56,59,共3页
Shanghai Medical Journal
关键词
黄芪
肾脏
缺血再灌注
细胞粘附分子-1
Astragalus
Kidney
Ischemia reperfusion
Intercellular adhesive molecule 1
