摘要
目的 研究反式曲马朵 (transT)在大鼠小肠中吸收的立体选择性。方法 高效毛细管电泳法测定小肠分段灌流液中transT对映体的浓度。结果 TransT对映体在小肠不同部位的吸收分数基本一致 ;在低浓度时 (+) transT的吸收分数明显低于 (- ) transT ;在高浓度时transT对映体的吸收分数降低 ,(+) transT与 (- ) transT的吸收分数无明显差别。结论 TransT在大鼠小肠的不同部位均能被吸收 ,具立体选择性 ,以 (- ) transT占优。
Aim To investigate the stereoselectivity in absorption of trans tramadol ( trans T) in rat intestine. Methods The duodenum, jejunum and ileum were separately perfusated in situ with trans T dissolved in Krebs-Ringer buffer. Trans T enantiomers in the perfusate were analyzed with a high performance capillary electrophoresis (HPCE) method. Results The absorbed fractions of trans T enantiomers were similar among the different segments of the rat intestine. The absorbed fraction of (+)- trans T was lower tha...
出处
《药学学报》
CAS
CSCD
北大核心
2003年第12期893-896,共4页
Acta Pharmaceutica Sinica
关键词
反式曲马朵
对映体
小肠中吸收
立体选择性
trans tramadol
enantiomer
intestinal absorption
stereoselectivity
