摘要
铁是生命必需的微量元素,它在氧的转运、脱氧核糖核酸的合成以及氧化还原反应中都起关键作用。一切生物有机体从细菌到人类,其生存都需要有铁的参与。绝大多数微生物通过制造它们自身结合铁的化合物-嗜铁素(Si-derophore)来获取铁,剥夺培养基中的铁可抑制细菌的生长,因此提出铁缺乏可能代表一种重要的防御机制。1973年Kochan提出"营养免疫"(Nutritional immunity)一词来强调剥夺铁是限制侵入微生物生长的一种关键机制。本文综述了近年来有关营养免疫机制研究的新进展。
The iron is an essential element for life. It plays key roles in oxygen-transport, oxidoreduction, and synthesis of deoxyribo-nucleic acid. All organism, from the bacteria to the mankind, need iron to living. The chemical compound that most microorganisms synthesized for combining iron is called Siderophore. The deprivation of iron can restrain the growth of bacteria in culture medium. So the absence of iron probably represents a kind of important defence mechanism. In 1973 Kochan had put forward a new term of 'nutritional immunity' for stressing iron deprivation is a kind of key mechanism to restrict the microorganism growth. The new progress of nutrition immunity in recent years has been summarized in this article.
出处
《免疫学杂志》
CAS
CSCD
北大核心
2004年第z1期129-132,共4页
Immunological Journal
关键词
铁
营养免疫
感染
<Keyword>on
Nutrition immunity
Infection
