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IgA肾病患者血清中白介素-12、白介素-15与尿蛋白的关系及临床意义

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摘要 目的探讨IgA肾病患者血清中白介素-12(IL-12)和白介素-15(IL-15)与尿蛋白关系及临床意义。方法60例IgA肾病患者按尿蛋白排泄量的多少分为3组:尿蛋白排泄量<1g/L(A组)、1~3g/L(B组)、>3g/L(C组)。IgA肾病治疗缓解后的自身对照30例,治疗(39±10)周后复查,患者每4周定期门诊随访。结果3组血清中IL-12、IL-15与尿蛋白定量多少无明显关系,与IgA肾病的病理分级及肾小球系膜区低糖基化-IgA之间均无明显关系。血清中IL-12、IL-15浓度在IgA肾病发病时增高,免疫抑制剂治疗缓解后降至正常。结论可以通过监测IgA肾病患者血清中IL-12、IL-15浓度来作为判断其治疗是否缓解的重要指标。
出处 《疑难病杂志》 CAS 2008年第9期550-551,共2页 Chinese Journal of Difficult and Complicated Cases
基金 2007年石家庄市科学技术研究与发展指导计划项目(No.07146273)
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