摘要
目的:探讨纳络酮注射液对一氧化碳中毒迟发性脑病大鼠模型细胞凋亡及Caspase-3表达的影响。方法:将30只大鼠随机分为正常对照组、一氧化碳中毒迟发性脑病大鼠模型对照组和纳络酮注射液治疗组,原位末端标记法(TUNEL)检测细胞凋亡,免疫组化法检测Caspase-3的表达。结果:治疗组大鼠脑细胞凋亡率及Caspase-3表达较迟发性脑病对照组显著降低(P<0.05)。结论:纳络酮注射液对一氧化碳中毒迟发性脑病的脑保护作用机制可能与干预脑细胞凋亡相关基因表达并减少神经细胞凋亡有关。
Objective:To observe the effects of Naloxone injection on cell apoptosis and the expression of caspase-3 in delayed encephalopathy rat model of carbon monoxide poisoning.Methods:Thirty rats were randomly divided into three groups is normal group,delayed encephalopathy rate model of carbon monoxide poisoning control group and Naloxone injection treatment group.The cell apoptosis was detected by TUNEL stacning.The expression of caspase-3 was determined by immunohistochemical staining.Results:The cell apoptosi...
出处
《陕西医学杂志》
CAS
北大核心
2008年第8期956-958,共3页
Shaanxi Medical Journal
