摘要
目的:了解艾芬地尔干预对氯化锂(LiCl)-匹罗卡品(Pilo)致大鼠脑电图随时间变化的特征。方法:通过腹腔注射LiCl-Pilo建立癫动物模型。60只雄性Wistar大鼠分为对照组、模型组和艾芬地尔干预组,分别在造模后第7、15、30、60天四个时间点观察各组大鼠行为、脑电图改变,每一个时间点5只大鼠。结果:对照组无性发作,经过4-20天的潜伏期后,干预组及模型组的脑电图波幅及频率骤然减低,在慢性期干预组较模型组的波幅逐渐增高,频率逐渐增快,但仍未达发作当时的水平,且两组间比较差异无统计学意义。干预组较模型组更早更快趋于正常化。结论:艾芬地尔在LiCl-Pilo致大鼠模型中具有抗惊厥作用,慢性期脑电图有特征性改变。
Objective:To understand the characteristics of EEG(electroencephalogram),which Ifenprodil intervented LiCl-Pilo(lithium chloride-pilocarpine,LiCl-Pilo)induced epilepsy in rats with the time changing.Methods:To establish the animal model of epilepsy by intraperitoneal injection of LiCl-Pilo.Sixty Wistar male rats were divided into three groups:control group,model group and Ifendilprol intervention group.To observe the characteristics of the EEG and behaviors on the 7th,15th,30th and 60th days after the exper...
出处
《临床神经电生理学杂志》
2008年第4期195-200,共6页
Journal of Clinical Electroneurophysiology
关键词
氯化锂-匹罗卡品
癫模型
脑电图
艾芬地尔
性放电
Lithium chloride-pilocarpine（LiCl-Pilo）
Epilepsy model
Electroencephalogram
Ifenprodil
Epileptic discharges
