摘要
目的观察兔激素性股骨头坏死凝血-纤溶系统指标的变化,探讨激素性股骨头坏死的发病机制。方法建立激素性股骨头坏死的动物模型,各组分别采血测定血浆抗凝血酶Ⅲ(AT-Ⅲ)、血栓调节蛋白(TM)、组织型纤溶酶原激活物(tPA)、纤溶酶原激活物抑制剂-1(PAI-1)的含量。结果1)凝血系统指标变化:AT-Ⅲ:给药24h后明显升高(P<0.05),然后开始下降,1周时下降最明显(P<0.05);TM:给药后24h开始升高(P<0.01),1周时升高最明显(P<0.01)。2)纤溶系统指标变化:tPA:给药后24h至2周时均明显降低(P<0.01);PAI-1:给药后24h至2周时均明显升高(P<0.01)。结论模型动物的凝血-纤溶系统存在明显功能障碍,这可能是激素性股骨头坏死的发病机制之一。
Objective To observe the changes in parameters of coagulation-fibrinolysis systems in rabbits with steroid-induced avascular osteonecrosis of femoral head(SANFH) and to investigate the pathogenesis of SANFH.Methods Experimental animal and grouping:Male adult New Zealand white rabbits,ranging in weight from 2.5 to 3.5 kg,were obtained from experimental center of Capital Medical University and randomly divided into seven groups including Group N(normal group);Groups M24 h,M48 h,M1,M2,M4,M6(model groups).Eight...
出处
《首都医科大学学报》
CAS
2008年第3期311-314,共4页
Journal of Capital Medical University
基金
首都特色临床医学技术发展研究(Y0905001000091)资助项目~~
关键词
激素
股骨头坏死
凝血
纤溶
steroid
avascular necrosis of the femoral head
coagulation
fibrinolysis
