摘要
目的研究注射用替卡西林钠/克拉维酸钾(TCS/CLP)的稳定性和有效期。方法用HPLC测定TCS/CLP的含量和有关物质,采用经典恒温法和初匀速法计算有效期。结果TCS/CLP在水溶液中的降解符合一级动力学方程。经典恒温法测得25℃时降解5%的时间分别为25.73、13.94 h。初匀速法测得值分别为24.89、14.00 h。结论两种方法测得数据基本一致,初匀速法可用于预测有效期。TCS/CLP在水溶液中不稳定,应随配随用。
OBJECTIVE To investigate the stability and expiration date of Ticacillin sodium(TCS) and Clavulanate potassium(CLP) injection solution.METHODSThe HPLC method was used to determine the contents and related substances of the solution.Classic isothermal kinetic method and initial uniform velocity method were applied to predict the expiration date of the solution.RESULTSIt was found that the TCS and CLP injection solution corresponded with the first-order kinetics.TCS declined by 5% in 25.73 h and CLP declined ...
出处
《华西药学杂志》
CAS
CSCD
北大核心
2008年第2期178-180,共3页
West China Journal of Pharmaceutical Sciences
关键词
注射用替卡西林钠/克拉维酸钾
高效液相色谱法
经典恒温法
初匀速度法
溶液稳定性
Ticacillin sodium and Clavulanate potassium for injection
HPLC
Classic isothermal kinetic method
Initial uniform velocity method
Solution stability
