摘要
目的:观察加味四物汤对白细胞减少证大鼠血及组织中超氧化物歧化酶(SOD)、脂质过氧化物(LPO)的影响。方法:选用wistar大鼠60只,随机分成6组:即生理盐水组、模型对照组、鲨肝醇组、中西药组、大剂量中药组、小剂量中药组。除生理盐水组外,其余5组均予环磷酰胺(Cy)腹腔注射。第一周按0.01 g/kg体重,给药二次;第二周按0.015 g/kg体重,给药一次;造成白细胞减少模型。从造模之日起分组进行治疗。第18天处死大鼠,测定大鼠血和组织中氧自由基清除能力和脂质过氧化物含量。结果:各治疗组均能增加血和组织中SOD活力,降低血及组织中LPO,与模型组比有显著差异P<0.01。中西药组疗效优于大剂量中药组和鲨肝醇组(P<0.01,P<0.05)。结论:加味四物汤能增加清除氧自由基能力,降低脂质过氧化物,而中西药组疗效最好。从而为中西医结合治疗白细胞减少症提供了理论依据。
Objective:To observe effect of the prescription of Jia Wei Si Wu Tang SOD and LPO in blood and tissue.Method:Sixty rats divided into physiological saline contrast group:model contrast group;Batioloi group;intergrated Chinese and western medicine group;big dose taditional Chinese medicine group;small does taditional Chinese medicine group.The five groups were injected cyclop hosphamide cytoxan(CTX 0.01 g/kg) two times in the first week,they in the second week cytoxan (CTX 0.015 g/kg) a time.At the same time,all rats were treated separately.Meanwhile,in the 18^(th) day animals was executed to detect the level of LPO and SOD.Results:The prescription can significantly increase the SOD level of blood and tissue and decrease the level of LPO compared with the model group.Among the treated groups,the group of Chinese and western medicine was the best.Conclusion:The prescription of substances can improve the abiIity of free scavenge.Treated group of Chinese and western medicine was better than other three treated groups,which provides the useful to treat the sympton of leukocyte decrease.
出处
《中国实验方剂学杂志》
CAS
2006年第12期51-53,共3页
Chinese Journal of Experimental Traditional Medical Formulae
