摘要
本文研究了当归提取物LIG的抗炎,解热活性。研究发现LIG(2.5,5,10 mg/kg)对角叉菜和右旋糖苷诱导的足肿胀的抑制率分别为22.2%,49.4%,76.5%和20.8%,44.2%,75.3%(P<0.001);对棉球肉芽肿的抑制率为29.2%,44.9%,58.8%(P<0.001);对小鼠白细胞迁移的抑制率为20.7%,35.6%,48.2%(P<0.001)。此外,LIG可降低啤酒酵母导致的高热(P<0.001)。并且,LIG的抗炎,解热作用均成剂量依赖性。以上结果显示LIG具有非常强的抗炎,解热活性。
In this study,the anti-inflammatory,analgesic and antipyretic effects of Z-ligustilide(LIG) extracted from Radix angelicae sinensis were investigated.The effects of LIG(2.5,5 and 10 mg/kg,ig) on acute and chronic phases of inflammation were studied in carrageenan-and dextran-induced paw edema and cotton pellet-induced granuloma,respectively.Antipyretic activity of LIG was evaluated in yeast-induced hyperpyrexia model in rats.In the anti-inflammatory studies,LIG showed significant dose-dependent inhibition of 22.2%,49.4% and 76.5% and 20.8%,44.2% and 75.3% in carrageenan-and dextran-induced paw edema,and 29.2%,44.9% and 58.8% in cotton pellet-induced granuloma,respectively(P<0.001).LIG also exhibited significant dose-dependent inhibition of peritoneal leukocyte migration in mice at the inhibition rate of 20.7,35.6 and 48.2%(P<0.001).Oral administration of LIG significantly reduced the elevated temperature in rats(P< 0.001).The results suggest that LIG possesses potent anti-inflammatory and analgesic activities.
出处
《天然产物研究与开发》
CAS
CSCD
2006年第5期751-755,共5页
Natural Product Research and Development
关键词
当归
抗炎
解热
足肿胀
肉芽肿
Angelicae sinensis
anti-inflammatory
antipyretic
paw edema
granuloma
