摘要
目的探讨血管内皮生长因子(VEGF)及其受体(VEGFR)在儿童急性白血病(AL)患者骨髓中的表达,分析其在化疗前后的变化。方法采用免疫组化S-P法检测53例AL患儿治疗前后以及对照组骨髓中VEGF/VEGFR(包括Flt-1和KDR两种)变化,分析其与临床特征的关系。结果VEGF,Flt-1,KDR在AL患儿骨髓中表达水平高于对照组。VEGF,Flt-1,KDR的表达于化疗达完全缓解(CR)后下调;化疗后未获得CR患儿VEGF,Flt-1,KDR的表达在化疗前后差异无统计学意义。骨髓中VEGF,Flt-1,KDR的表达水平在不同年龄、性别、有无髓外浸润间差异无统计学意义。结论VEGF,Flt-1,KDR在儿童AL中呈高表达,化疗后表达明显降低,说明VEGF可以作为评价儿童AL化疗反应的指标。
Objective To investigate the expressions of VEGF/VEGFR in bone marrow of children with acute leukemia, and to observe changes before and after chemotherapy. Methods The bone marrows of 53 children with acute leukemia were assayed to study the expression of VEGF/VEGFR(KDR, Flt-1 )before and after chemotherapy with S-P immonohistochemical staining. Their relations to the clinical features were evaluated. Results The expressions of VEGF, Flt-1, KDR were significantly higher in newly diagnosed children with tha...
出处
《白血病．淋巴瘤》
CAS
2006年第4期255-256,259,共3页
Journal of Leukemia & Lymphoma
基金
河南省教育厅资助课题(20023200004)
