摘要
转录因子结合位点的计算预测是研究基因转录调控的重要环节,但现有算法的预测特异性偏低.在深入分析转录因子结合位点生物特征的基础上,对当前基于保守模体和基于比较基因组学的两类计算预测方法进行了综述,指出了方法各自的优点和不足,并探讨了可能的改进方向.
Computational prediction of transcription factor binding sites is an essential task in the research of transcription regulation,but the specificity of recognition results achieved by the current algorithms is quite low.According to the thorough analysis about biologic features of transcription factor binding sites,two classes of predicting methods,based on motif signals and comparative genomics,are reviewed respectively.For each method,besides the merits and defects,the possible directions for improvement a...
出处
《生命科学研究》
CAS
CSCD
2006年第S1期24-31,共8页
Life Science Research
基金
国家自然科学基金资助项目(60471003)
关键词
转录因子结合位点
计算预测
模体
比较基因组学
transcription factor binding site（TFBS）
computational prediction
motif
comparative genomics
