摘要
我们以牛跟腱和酸性成纤维细胞生长因子(acidic fibroblast growth factor,aFGF)为原料,研制了一种新型的创伤敷料——aFGF/胶原蛋白复合海绵,并检测了其物理性能和组织相容性,特别是在血液相容性方面,研究其作为医用生物材料的安全性。结果显示:制备的高剂量和低剂量aFGF/胶原蛋白复合海绵的急性毒性试验、刺激性试验结果均为阴性;复钙试验表明aFGF/胶原蛋白复合海绵复钙时间较长,具有较好的抗凝特性;溶血试验表明复合海绵对红细胞的破坏很小,符合生物材料的溶血性要求;血小板黏附试验表明aFGF/胶原蛋白复合海绵的血小板黏附量较少且未被激活,对血小板没有明显的破坏作用。结果表明,aFGF/胶原蛋白复合海绵具有较好的组织相容性,具备临床应用的可能性。
A new type wound dressing—aFGF/collagen composite sponge was prepared by bovine tendon and aFGF. Its physical function, biocompatibility, and hemocompatibility in particular,were studied for full assurance of its biosafety. The acute toxicity and skin irritation tests of composite sponge of high and low doses were negative. Recalcification test demonstrated that the recalcification time of composite sponge was much longer than that of the control group. Hemolysis test revealed that the composite sponge did ...
出处
《生物医学工程学杂志》
CAS
CSCD
北大核心
2008年第3期578-583,共6页
Journal of Biomedical Engineering
基金
国家自然科学基金资助项目(30670541)
