阿托伐他汀联用雷米普利对急性冠脉综合征抗炎效应的临床研究被引量：1

Clinic study on anti-inflammatory effects of atorvastatin associated with rampril in patients with acute coronary syndrome

下载PDF

导出

摘要目的:观察阿托伐他汀及雷米普利对急性冠脉综合征(ACS)时血脂、血清C-反应蛋白(CRP)水平的影响。方法:随机将ACS患者分为对照组、标准剂量阿托伐他汀组、大剂量阿托伐他汀组及大剂量阿托伐他汀联用雷米普利组。分别测定治疗前及30d干预后患者血清CRP和血脂浓度的变化。结果:治疗30d后,对照组与标准剂量阿托伐他汀组血脂水平无明显降低(P>0.05),大剂量阿托伐他汀组及大剂量阿托伐他汀联用雷米普利组血脂水平降低显著低于对照组及标准剂量阿托伐他汀组(P<0.05);4组ACS患者CRP水平均明显降低(P<0.05),大剂量阿托伐他汀组及大剂量阿托伐他汀联用雷米普利组CRP水平降低显著低于对照组及标准剂量阿托伐他汀组(P<0.05),大剂量阿托伐他汀联用雷米普利组CRP水平较大剂量阿托伐他汀组有显著降低(P<0.05);血清CRP水平与TC、LDL-C水平的变化无相关性。结论:ACS的发生与机体炎症反应激活有关,在ACS早期应用大剂量阿托伐他汀能迅速降低血清CRP和血脂水平,且这是一种独立于降脂作用之外的抗炎效应。 Objective:To investigate the anti-inflammatory effect of atorvastatin associated with rampril in acute coronary syndromes(ACS) with C-reactive protein(CRP) reduction.Methods:Patients with ACS were assigned to four groups:control group,standard dose atorvastatin group,high dose atorvastatin group and high dose atorvastatin associated with rampril group.CRP levels and lipid profiles were measured at first and 30 days later.Results:The study suggested:(1) lipid profiles levels didn t alter significantly in con...

作者吕景云张玉顺

机构地区北京大学医院内科第四军医大学西京医院

出处《陕西医学杂志》 CAS 北大核心 2008年第2期219-221,共3页 Shaanxi Medical Journal

关键词冠状动脉疾病 C-反应蛋白阿托伐他汀雷米普利 Acute coronary syndrome C-reactive protein Atorvastatin Rampril

分类号 R541.4 [医药卫生—心血管疾病]

引文网络
相关文献

参考文献8

1[1]Ross R.Atherosclerosis-an inflammatory disease.New Engl J Med,1999,340:115-126. 被引量：1
2[2]The Long-term Intervention with Pravastatin in Ischaemic Disease (LIPID) Study Group.Prevention of cardiovascular events and death with pravasatin in patients with coronary heart disease and abroad range of initial cholesterol levels.New Engl J Med,1998,339:1349-1357. 被引量：1
3[3]Downs JR,Clearfield M,Weis S,et al.Primary prevention of acute coronary events with lovastatin in men and women with average cholesterol levels:results of AFCAPS/TexCAPS.JAMA,1998,279:1615-1622. 被引量：1
4[4]Ridker PM,Rifai N,Rose L,et al.Comparison of C-reaction protein and low density lipoprotein cholesterol levels in the prediction of first cardiovascular events.New Engl J Med,2002,347:1557-1565. 被引量：1
5[5]Libby P,Ridker P,Maser IA.Inflammation and atherosclerosis.Circulation,2002,105:1135-1143. 被引量：1
6[6]Jerffery L,Anderson MD,Facc JF,et al.Evaluation of C reactive protein,an inflammatory marker and infectious serology as risk factors for coronary disease and myocardial infarction.J Am Coll Cardiol,1998,32:35-42. 被引量：1
7[7]Tataru MC,Heinrich J,Junker R,et al.C reactive protein and the severity of atherosclerosis in myocardial infarction patients with stable angina pectoris.Eur Heart J,2001,21:1000-1006. 被引量：1
8[8]Cannon CP,Braunwald E,Mccabe C,et al.PROVE IT TIMI 22 study.Comparison of intensive and moderate lipid lowering with statins after acute coronary syndromes.New Engl J Med,2004,320:1495-1500. 被引量：1