摘要
目的对两种来源的马尔尼菲青霉(Penicillium marneffei,PM)菌株的致病过程和致病力情况进行初步探讨。方法分别将野生株和临床分离株的PM孢子菌悬液经腹腔注射途径感染健康小鼠,然后按时间分批处死,观察脏器感染情况,取其内脏及颈动脉血进行真菌培养并比较阳性率。结果发现小鼠感染PM的发病率为100%;不同时期小鼠内脏病变程度有差异,且内脏病变程度随着时间推移而逐渐减轻;小鼠部分脏器真菌培养阳性率有明显差异。结论不同来源的PM菌株经腹腔注射途径均可使小鼠致病;具有正常免疫功能的小鼠感染PM后可以逐渐恢复;本实验可以作为研究马尔尼菲青霉病(Penicilliosis marneffei,PSM)及PM野生株和临床分离株致病力相关性等的一个手段。
The process of pathopoiesis and virulence of Penicillium marneffei wide type and clinical isolates were investigated ,in which the spore-suspension of P marneffei was injected intra-abdominally into mice and they were killed in batch to observe the infectio status of internal organs. Meanwhile,bloods taken from internal organs and carotid artery were cultivated to isolate P marneffei and the rates of positive detection of wide type and clinical isolates were compared. It was found that the incidence of mice...
出处
《中国人兽共患病学报》
CAS
CSCD
北大核心
2008年第3期240-242,246,共4页
Chinese Journal of Zoonoses
基金
国家自然科学基金资助项目(30560143)
