摘要
目的:糖尿病是心脏手术后发病率和死亡率的重要预测因素,但其原因仍不明确。因此,本研究旨在阐明人类缺血和非缺血糖尿病心肌的细胞死亡是否比非糖尿病心肌更多,并探讨潜在的机制。
Objectives: Diabetes is an important predictor of morbidity and mortality after cardiac surgery,but the reason is unclear. The aims of these studies,therefore,were to elucidate whether cell death is greater in ischemic and nonischemic diabetic human myocardium than in nondiabetic myocardium and to investigate the underlying mechanism. Methods: The right atrial appendages(n=8 per group) of patients without diabetes and patients with type 1 and 2 diabetes were subjected to 90 minutes of simulated ischemia and...
