摘要
目的:探讨是否增加氯吡格雷维持剂量能增强对血小板聚集的抑制作用。方法和结果:60例经600mg氯吡格雷预治疗的患者在接受成功PCI术后12h内被纳入研究,以随机、双盲方式分为两组,分别接受氯吡格雷75mg/d或150mg/d治疗。PCI术后30d,分别采用光学聚集度测定和即时检测(VerifyNowTMP2Y12)方法测量血小板功能。
Aims: We sought to test whether an increase in the clopidogrel maintenance dose results in increased inhibition of platelet aggregation. Methods and results: Sixty patients after pretreatment with 600 mg of clopidogrel and within 12 h after successful PCI were included in this trial. They were allocated to receive one of two clopidogrel daily maintenance doses(75 or 150 mg) for 30 days in a double-blind randomized manner. Platelet function was evaluated 30 days after the intervention with optical aggregomet...
