摘要
[目的]探讨沙利度胺联合小剂量MP方案化疗治疗老年多发性骨髓瘤的临床疗效及不良反应。[方法]治疗组12例采用沙利度胺联合小剂量MP方案化疗,沙利度胺自化疗开始时给药,剂量200 mg/d分早、晚口服,以后每周加量50 mg,至300 mg^400 mg/d长期治疗。化疗方案采用小剂量MP方案,马法兰6 mg/d,第1~8天,泼尼松50 mg/d,第1~8天,15 d为一个疗程,连续治疗6个疗程。对照组14例,单纯应用小剂量MP方案化疗,方法及药物剂量均同治疗组。[结果]治疗组部分缓解7例,进步3例,无效2例,总有效率83.33%,明显高于对照组(总有效率57.14%)(P<0.01)。治疗组各种疗效指标改善率均优于对照组(P<0.01~P<0.05)。常见不良反应有便秘、腹胀、纳差、头晕、嗜睡及皮疹等,经调整药物剂量或对症治疗后,均可缓解,未出现严重不良反应。[结论]沙利度胺联合小剂量MP方案化疗治疗老年多发性骨髓瘤具有副作用小、耐受性好、疗效明显等优点,对老年多发性骨髓瘤的治疗不失为一个好的治疗方法,值得推广应用。
[Objective] To explore the effectivity and adverse reaction of thalidomide combined small-dose MP plan in treatment of senile multiple myeloma(MM).[Method] The experiment group were treated by thalidomide combined small-dose MP plan,the controlled group were treated by small-dose MP plan singlely.[Result] Seven patiences of the experiment group had a partly recession,3 patiences for progress and 2 for ineffectivity.the total effective rate is 83.33%,which was obviously higher than that of the controlled gro...
出处
《大连医科大学学报》
CAS
2007年第3期249-251,共3页
Journal of Dalian Medical University
关键词
沙利度胺
老年多发性骨髓瘤
疗效
不良反应
thalidomide
senile multiple myeloma（MM）
`effectivity
adverse reaction
