摘要
目的研究99Tcm-奥曲肽眼眶显像在判断甲状腺相关眼病(TAO)患者眼部炎性反应活动度中的临床价值。方法根据临床活动度评分(CAS)标准,将30例TAO患者分为活动组和非活动组,11例正常志愿者为对照组。所有对象行99Tcm-奥曲肽眼眶断层显像,并计算眼眶奥曲肽摄取比值(UR)。6例活动组患者于抗炎治疗后进行了二次显像。结果3组眼眶的奥曲肽UR均数分别为1·40±0·18、1·15±0·10及1·07±0·20,活动组与非活动组、对照组两两相比,差异均有统计学意义(均P<0·001);非活动组与对照组相比,差异无统计学意义(P>0·05)。所有TAO患者的UR与其CAS具有良好的相关性(rall=0·859,P<0·001)。对活动组患者的治疗前后UR比较,差异有统计学意义(t=4·39,P=0·007)。治疗前后CAS比较,差异有统计学意义(Z=-5·51,P<0·001),表明治疗后评分降低,治疗有效。结论99Tcm-奥曲肽眼眶显像可帮助临床医师判断TAO炎性反应活动度,为制订治疗方案提供依据,并可用于疗效评价。
Objective To analyze the feasibility of estimation of thyroid associated ophthalmopathy (TAO) activity with orbital scintigraphy using ~ 99 Tc^m-octreotide. Methods There were 30 cases of TAO and 11 volunteers without eye disease or thyroid disease (control group, CG). Some examinations were performed before treatment. Based on the clinical activity score (CAS), all TAO patients were divided into 2 groups, active group (AG) and inactive group (IAG). Orbit scintigraphy study of orbit was completed within 1.0...
出处
《中华眼科杂志》
CAS
CSCD
北大核心
2006年第12期1068-1072,共5页
Chinese Journal of Ophthalmology
关键词
格雷夫斯病
受体
生长抑素
放射性核素显像
奥曲肽
锝
Graves′ disease
Receptors
somatostatin
Radio nuclide imaging
Octreotide
Technetium
