摘要
医用明胶是由猪皮经特殊工艺加工制成的一种由角蛋白质类组成的复合物。是外科目前止血明胶海绵和医用植入型药物常用的赋形剂,在医药工业上具有广泛的用途。医用明胶的药代动力学参数未见文献报道,然而,这些资料又为临床医生和制药工业十分关注。本文利用^(125)I示踪技术,客观地反映出明胶在体内的运转和药代过程。
^(125)I-labeled gelatin sponge was made by special technique. Healthy adult rabbits were anaesthetized by amytal. Then the thigh-bone was exposed and drilled a hole. The bone marrow and bone substance were taken out and the bone-cave was planted with ^(125)I-gelatin sponge. At 14 or 30 days after planing, the radioactivities of the liver, lung, kidney, genitals as well as the blood (obtained from car-vein every two days after planting)were measured. The results, showed that the radioactivity remained high i...
出处
《同位素》
CAS
北大核心
1992年第3期148-152,共5页
Journal of Isotopes
