摘要
髓系细胞触发受体2(TREM2)是近年来发现的阿尔茨海默病(AD)的重要风险基因,在AD的发生和进展中发挥着重要作用。本文从AD中淀粉样蛋白及其与TREM2的相互作用、TREM2过表达增强与β淀粉样蛋白(Aβ)相互作用来减弱Aβ病理、Aβ磷酸化修饰增强与TREM2相互作用调节小胶质细胞摄取和针对可溶性TREM2的靶向治疗可能通过调节小胶质细胞活化清除Aβ几个方面进行综述,为进一步了解TREM2在Aβ病理致AD中的作用机制和AD的治疗提供参考。
The triggering receptor expressed on myeloid cells-2(TREM2)has been identified as a significant risk factor for Alzheimer's disease(AD)in recent years.It plays an important role in the development and progression of AD.In this paper,we review amyloidβ-protein(Aβ)and its interaction with TREM2 in AD,TREM2 overexpression enhancing interaction with Aβto attenuate Aβpathology,Aβphosphorylation modification enhancing interaction between Aβand TREM2 to regulate microglial uptake,and targeted therapies against sTREM2 to potentially clear Aβby regulating microglial activation,so as to further understand the mechanism of TREM2 in Aβpathogenesis,and to provide reference for the treatment of AD.
作者
陆静
钟为慧
赵杰
曾玲晖
Lu Jing;Zhong Weihui;Zhao Jie;Zeng Linghui(College of Pharmaceutical Sciences,Zhejiang University of Technology,Huzhou 310014,China;School of Medicine,Hangzhou City University,Hangzhou 310015,China)
出处
《中华老年病研究电子杂志》
2024年第1期51-56,共6页
Chinese Journal of Geriatrics Research(Electronic Edition)
基金
浙江省自然科学基金资助项目(LTGD23C050001)
