摘要
目的观察依达拉奉右莰醇注射用浓溶液治疗急性前循环缺血性脑卒中的短期临床疗效。方法回顾性连续收集南京医科大学附属淮安第一医院2020年8月至12月收治的80例未接受静脉溶栓治疗或血管内治疗的急性前循环缺血性脑卒中患者,其中观察组(32例)使用常规治疗+依达拉奉右莰醇注射用浓溶液治疗,对照组(48例)仅使用常规治疗,均治疗14 d。采用独立样本t检验比较2组患者入院时、治疗后7 d及14 d美国国立卫生研究院卒中量表(NIHSS)评分的差异。采用χ^(2)检验比较2组治疗后7 d及14 d总有效率的差异。结果2组患者治疗前基线NIHSS评分比较,差异无统计学意义(P>0.05),观察组治疗后7 d及14 d NIHSS评分均低于对照组[(6.31±4.81)分vs(8.48±4.77)分;(4.40±2.95)分vs(6.56±4.27)分],差异均具有统计学意义(t=-2.167,P=0.033;t=-2.485,P=0.015)。观察组治疗后7 d及14 d总有效率均高于对照组(90.63%vs70.83%;96.88%vs77.08%),差异均具有统计学意义(χ^(2)=4.494,P=0.034;χ^(2)=5.899,P=0.015)。结论使用依达拉奉右莰醇注射用浓溶液治疗能短期内有效改善急性前循环缺血性脑损伤。
ObjectiveTo observe the short-term clinical effect of Edaravone Dexborneol injection for acute anterior circulatory ischemic stroke.MethodsA retrospective study of 80 patients with acute anterior circulatory ischemic stroke admitted to the Affiliated Huai'an No.1 People's Hospital of Nanjing Medical University from August to December 2020 without intravenous thrombolysis or endovascular treatment was conducted.The observation group(32 cases)was treated with conventional treatment combining Edaravone Dexborneol injection,while the control group(48 cases)was treated with only conventional treatment.Both groups were treated for 14 days.Independent samplet-test was used to compare the National Institute of Health stroke scale(NIHSS)scores at admission,714 days after treatment.The total efficacy of the two groups on 7 and 14 days after treatment was compared by chi-square test.ResultsNo statistically significant difference was observed in NIHSS scores of the two groups at baseline before treatment(P>0.05).NIHSS score of the observation group on 7 and 14 days after treatment were lower than those of the control group[(6.31±4.81)vs(8.48±4.77);(4.40±2.95)vs(6.56±4.27)],and the differences were statistically significant(t=-2.167,P=0.033;t=-2.485,P=0.015).The total efficacy of the observation group on 7 and 14 days after treatment were higher than those of the control group(90.63%vs70.83%;96.88%vs77.08%),and the differences were statistically significant(χ^(2)=4.494,P=0.034;χ^(2)=5.899,P=0.015).ConclusionEdaravone Dexborneol injection was effective in short time for acute anterior circulatory ischemic brain injury.
作者
吴嶛
孙颖
倪小宇
倪贵华
Wu Liao;Sun Ying;Ni Xiaoyu;Ni Guihua(Department of Neurology,the Affiliated Huai'an No.1 People's Hospital of Nanjing Medical University,Huai'an 223300,China)
出处
《中华脑血管病杂志（电子版）》
2022年第4期253-257,共5页
Chinese Journal of Cerebrovascular Diseases(Electronic Edition)
