摘要
目的对比研究国产新型非交联脱细胞基质材料生物补片与交联生物补片在青少年和青壮年腹股沟疝治疗中的临床疗效,从而为青少年和青壮年这一特定人群的腹股沟疝治疗提供新材料。方法采用单中心、前瞻性、随机对照研究,收集分析首都医科大学附属北京朝阳医院疝和腹壁外科2019年6月至2020年12月收治的120例青少年和青壮年腹股沟疝患者的临床资料,其中男性112例,女性8例,平均年龄32岁(13~45岁);按照随机数字表法分为2组,60例患者使用国产新型非交联脱细胞基质材料生物补片行李金斯坦疝修补手术,设为试验组,60例患者使用交联生物补片行李金斯坦修补手术,设为对照组,比较2组患者的临床指标。结果试验组和对照组的手术时间、术中出血量、住院时间均无统计学差异(P>0.05);住院费用比较,试验组明显低于对照组,差异有统计学意义(P<0.05)。试验组术后1周血清肿发生率明显高于对照组(38.3%vs20.0%,P<0.05),但2组患者在术后1个月及3个月血清肿发生率差异无统计学意义(P>0.05)。试验组随访时间(20.17±5.57)个月,对照组随访时间(19.45±5.70)个月,2组患者均未出现慢性疼痛、异物感、睾丸缺血/萎缩、伤口感染、补片感染等术后并发症。结论国产新型非交联脱细胞基质材料生物补片治疗青少年和青壮年腹股沟疝安全有效,与交联生物补片临床疗效相当,是治疗青少年和青壮年腹股沟疝所需材料的另一选择。
Objective A comparative study was conducted on the clinical efficacy of domestic new non-crosslinked acellular matrix biological mesh and crosslinked biological mesh in the treatment of inguinal hernia in adolescents and young adults,to provide new materials in treatment of inguinal hernia for this population.Methods A single-center,prospective,randomized controlled study was conducted.Clinical data of 120 adolescent and young adults with inguinal hernia who were treated in the Department of Hernia and Abdominal Wall Surgery of Beijing Chaoyang Hospital,Affiliated to Capital Medical University from June 2019 to December 2020 were collected and analyzed.There were 112 males and 8 females with an average age of 32 years(13~45 years).The patients were divided into 2 groups according to the random number table method.60 patients in experimental group underwent Lichtenstein repair with domestic new non-crosslinked acellular matrix biological mesh;60 patients in control group underwent Lichtenstein repair with cross-linked biological mesh.Data of clinical indicators of the two groups were compared.Results There were no significant differences in operative time,intraoperative blood loss and hospital stay between the experimental group and the control group(P>0.05).The hospitalization cost of the experimental group was significantly lower than that of the control group(P<0.05).Seroma rate in the experimental group at 1 week after operation was significantly higher than that in the control group(38.3%vs20.0%,P<0.05),but there was no significant difference between the two groups at 1 month and 3 months postoperatively(P>0.05).The follow-up time in experimental group and control group was(20.17±5.57)months and(19.45±5.70)months,respectively.No patients developed postoperative chronic pain,foreign body sensation,testicular ischemia/atrophy,wound infection and mesh infection during the follow-up duration in both groups.Conclusion The domestic new non-crosslinked acellular matrix biological mesh is safe and effective in the
作者
刘静
劳金涛
申英末
Jing Liu;Jintao Lao;Yingmo Shen(Department of Hernia and Abdominal Wall Surgery,Beijing Chaoyang Hospital Capital Medical University,Beijing 100020,China;The Third Clinical Medical College of Capital Medical University,Beijing 100020,China)
出处
《中华疝和腹壁外科杂志（电子版）》
2022年第6期672-676,共5页
Chinese Journal of Hernia and Abdominal Wall Surgery(Electronic Edition)
基金
吴阶平医学基金会临床科研专项资助基金(320.6750.19091-4)
关键词
疝
腹股沟
疝修补术
生物补片
疗效
Hernia
inguinal
Herniorrhaphy
Biological mesh
Efficacy
