摘要
牙源性间充质干细胞(DMSC)是一种来源于哺乳动物牙齿相关组织的间充质干细胞,其具有自我更新、多向分化和免疫调节等功能,且容易获得,对组织工程学和再生医学具有重要的研究意义。线粒体是高度动态的细胞器,通过不断地分裂和融合来维持其形态,也称为线粒体动力学。研究表明,线粒体动力学是决定干细胞命运的关键因素。线粒体分裂和融合的协调对细胞功能和应激反应至关重要,而异常的分裂和融合导致干细胞功能障碍。近年来研究证实,DMSC在增殖、分化、凋亡和衰老过程中经历特定的线粒体动力学过程。本文就线粒体动力学分子调控的机制以及间充质干细胞线粒体的形态特征,线粒体动力学在生理和应激微环境下对DMSC行为的调控作用作一综述。
Dental mesenchymal stem cells(DMSCs)are derived from mammalian tooth-related tissues,which have the functions of self-renewal,multi-directional differentiation and immunomodulation.They have important research values in tissue engineering and regenerative medicine.Mitochondria,known as mitochondrial dynamics,are highly dynamic organelles that maintain their morphology through continuous division and fusion.Studies have shown that mitochondrial dynamics is a key factor in determining the fate of stem cells.The coordination of mitochondrial division and fusion is vital for cell function and stress response,while abnormal dynamic may lead to the dysfunction of stem cells.Recent studies have confirmed that DMSCs undergo specific mitochondrial dynamics in the process of proliferation,differentiation,apoptosis or senescence.This article reviewed the molecular regulation mechanism of mitochondrial dynamics,the morphological characteristics of mesenchymal stem cell mitochondria,and the role of mitochondrial dynamics in regulating DMSCs behavior in physiological and stress microenvironment.
作者
黄珞
梁爱琳
龚启梅
Luo Huang;Ailin Liang;Qimei Gong(Hospital of Stomatology,Guanghua School of Stomatology,Sun Yat-sen University,Guangdong Provincial Key Laboratory of Stomatology,Guangzhou 510055,China)
出处
《中华口腔医学研究杂志（电子版）》
CAS
2022年第6期352-357,共6页
Chinese Journal of Stomatological Research(Electronic Edition)
基金
国家自然科学基金(81870750)
