摘要
目的总结新生儿坏死性小肠结肠炎(necrotizing enterocolitis,NEC)保守治疗后因肠狭窄行手术治疗患儿的临床特点和诊治经验,比较NEC单发与多发肠狭窄的预后情况。方法回顾性分析2014年1月至2020年12月复旦大学附属儿科医院新生儿外科收治的67例行NEC保守治疗后发生肠狭窄且接受手术治疗患儿的临床资料,收集患儿基本信息、NEC发病情况、肠狭窄术前检查、手术情况及术后恢复情况,分析NEC保守治疗后的临床特点及与肠狭窄发生之间的关系、手术预后以及诊治经验。将肠狭窄患儿分为单发狭窄组和多发狭窄组,比较两组预后情况。结果67例行NEC保守治疗后出现肠狭窄的患儿中,术前经肛门造影阳性率为83.9%(47/56)。60例行一期肠切除肠吻合术,7例行肠造瘘术。中位手术时间为发生NEC后第39天,中位手术时体重为2.53 kg。术中证实单发肠狭窄34例(34/67,50.7%),多发肠狭窄33例(33/67,49.3%)。共123处狭窄,除1处狭窄横跨小肠和结肠(自末端回肠至乙状结肠)以外,小肠狭窄65处[以末端回肠为主(37处)],结肠狭窄57处[以升结肠为主(27处)]。2例术后放弃治疗,2例一期吻合患儿因病情加重改行肠造瘘术,其中1例死亡,1例于术后12个月关闭造瘘。6例出院后出现并发症,其中肠管脱垂2例,黏连性肠梗阻4例;其余61例均恢复良好。手术治疗NEC保守治疗后肠狭窄的长期存活率为95.5%(64/67)。多发狭窄组切除肠管长度和手术时间显著长于单发狭窄组,差异有统计学意义(P<0.05);但两组达到全肠内喂养时间和术后并发症情况比较,差异无统计学意义(P>0.05)。结论NEC保守治疗后肠狭窄的发生率虽然不高,但多发狭窄比例较高;且狭窄好发于末端回肠和结肠,术前下消化道造影阳性率较高。术中应仔细探查、彻底切除狭窄段;多发狭窄通常不影响术后恢复及预后。
Objective To summarize the clinical features of intestinal stricture after conservative measures for neonatal necrotizing enterocolitis(NEC)and compare the outcomes of single and multiple stricture groups.Methods From January 2014 to December 2020,retrospective review was performed for the relevant clinical data of 67 neonates operated for post-NEC intestinal strictures.Basic information,NEC onset time,Bell stage,radiographic studies,surgical approach postoperative complications were recorded.Then they were assigned into two groups of single stricture and multiple strictures and the prognosis between two groups were compared.Results Positive rate of preoperative contrast enema was 83.9%.Primary end-to-end anastomosis(n=60)and enterostomy(n=7)were performed at a median of 39 days after NEC with a median weight of 2.53 kg.Multiple strictures were detected in 33 neonates(49.3%)while the remainders had only 1 stricture.There were a total of 123 strictures.Except for 1 stricture spanning small intestine and colon(from terminal ileum to sigmoid colon),65 strictures were present in small intestine,including terminal ileum(n=37)and colon(n=57)(ascending colon,n=27).Two cases underwent enterostomy later due to disease deterioration and 1 died at Month 2 after discharge.Another child accepted enterostomal closure 12 months later.Complications included intestinal prolapse(n=2)and adhesive intestinal obstruction(n=4).The long-term survival rate of intestinal strictures after conservative measures was 95.5%(64/67).Length of bowel resection(P<0.001)and operative duration(P=0.008)were significantly longer in multiple-stricture group than those in single-stricture group.However,no significant inter-group difference existed in time to complete enteral feeding(P=0.862)or postoperative complications(P=0.347).Conclusions Despite a low incidence of intestinal strictures after conservative measures for NEC,multiple strictures account for a large proportion.The strictures occur predominantly in terminal ileum and colon.Contrast enema i
作者
曹旭清
潘晓雪
沈淳
Cao Xuqing;Pan Xiaoxue;Shen Chun(Department of Pediatric Surgery,Children's Hospital of Fudan University,National Children's Medical Center,Shanghai 201102,China)
出处
《临床小儿外科杂志》
CAS
CSCD
北大核心
2024年第2期135-139,共5页
Journal of Clinical Pediatric Surgery
基金
国家自然科学基金面上项目(81873849)
关键词
坏死性小肠结肠炎
保守治疗
肠狭窄
婴儿
新生
Necrotizing Enterocolitis
Conservative Treatment
Intestinal Stricture
Infant,Newborn
