摘要
第5版WHO甲状腺肿瘤分类提出高级别非间变性甲状腺滤泡源性癌,包括传统甲状腺低分化癌(PDTC)和高级别分化型甲状腺癌(DHGTC),预后介于高分化甲状腺癌和间变性甲状腺癌(ATC)之间,其中约50%患者放射性碘不摄取,因而该分类具有重要临床意义。本文对第5版WHO高级别非间变性甲状腺滤泡源性癌病理诊断标准及其分子特征进行解读,并与ATC进行比较。
The 5^(th)edition WHO classification of thyroid tumors proposed high-grade non-anaplastic thyroid carcinoma,which includes traditional poorly differentiated thyroid carcinoma(PDTC)and differentiated high-grade thyroid carcinoma(DHGTC),with a prognosis between highly differentiated thyroid carcinoma and anaplastic thyroid carcinoma(ATC),in which about 50%of patients do not take radioactive iodine.Therefore,this classification is of great clinical significance.This article interprets the diagnostic criteria and genetic features of high-grade non-anaplastic thyroid carcinoma in 5^(th)edition WHO classification,comparing with ATC.
作者
周隽
刘志艳
Zhou Juan;Liu Zhiyan(Department of Pathology,Shanghai Jiao Tong University Affiliated Sixth People′s Hospital,Shanghai 200233,China)
出处
《中华医学杂志》
CAS
CSCD
北大核心
2024年第18期1578-1583,共6页
National Medical Journal of China
基金
国家自然基金面上项目(81972500)
上海市2023年度“科技创新行动计划”自然科学基金(23ZR1448200)
上海市2020年度“科技创新行动计划”医学创新研究专项(20Z11900304)
关键词
甲状腺肿瘤
高级别非间变性甲状腺滤泡源性癌
甲状腺低分化癌
高级别分化型甲状腺癌
间变性甲状腺癌
Thyroid neoplasms
High-grade follicular cell-derived non-anaplastic carcinoma
Poorly differentiated thyroid carcinoma
Differentiated high-grade thyroid carcinoma
Anaplastic thyroid carcinoma
