摘要
目的研究分次立体定向放疗在中等大小脑寡转移肿瘤中的临床效果。方法回顾性分析2017—2019年间徐州市中心医院放疗科收治的颅内新发寡转移瘤患者34例,共计52个转移病灶且单个病灶最大直径均≤4.0cm。使用立体定向放疗27Gy分3次方案。分析局部控制率及治疗相关不良反应。采用Cox模型分析局部控制率的影响因素。结果中位随访时间7个月(2~30个月)。6个月和1年局部控制率分别为94%和80%。Cox模型回归分析提示肿瘤直径是影响局部控制率的唯一因素(HR=7.45,95%CI为1.16~78.54,P=0.035)。所有患者均顺利完成治疗计划,至随访结束均未见≥3级治疗相关不良反应。结论27Gy分3次方案似乎对颅内寡转移病灶有较好的局部控制率,不良反应可耐受。
Objective To investigate the efficacy and safety of fractionated stereotactic radiotherapy(FSRT)for medium-sized oligo brain metastases.Methods Between 2017 and 2019,a total of 34 patients with newly diagnosed brain metastases(n=52)of no more than 4.0 cm had been treated with FSRT.All patients received prescription dose 27 Gy in 3 fractions of each tumor.The local control rate(LCR)were conducted using Cox model.Treatment outcomes were measured by tumor response,LCR and the treatment-related toxicity.Results The median follow-up time was 7 months(range:2-30 months).In this study,the 6-and 12-months LCR was 94%and 80%respectively.The Cox model analysis showed that the tumor size was the independent prognostic factor(HR=7.45,95%CI:1.16-78.54,P=0.035).No patient experienced grade 3 toxicity.Conclusion The 27 Gy in 3 fractions scheme seems to be an effective and safe treatment for limited number brain metastases.
作者
周冲
张伟
任洪荣
郝大为
管峦
殷海涛
Zhou Chong;Zhang Wei;Ren Hongrong;Hao Dawei;Guan Luan;Yin Haitao(Department of Radiotherapy,Xuzhou Central Hospital,Xuzhou 221009,China)
出处
《中华转移性肿瘤杂志》
2021年第4期298-301,共4页
Chinese Journal of Metastatic Cancer
基金
国家自然科学基金(81672973)
关键词
肿瘤
脑转移/分次立体定向放射疗法
治疗结果
Neoplasms,brain metastases/fractionated stereotactic radiotherapy
Treatment outcome
