摘要
Objective:TTo study the protective effect of adenosine cyclophosphate combined with vitamin C antiviral therapy on myocardial injury in children with viral myocarditis.Methods: 88 cases of children with viral myocarditis treated in Ningde Hospital of Traditional Chinese Medicine of Fujian University of Traditional Chinese Medicine between June 2014 and September 2016 were selected and randomly divided into the intervention group and the control group who received adenosine cyclophosphate combined with vitamin C antiviral therapy and conventional therapy respectively. Serum levels of myocardial injury indexes, antioxidant indexes and collagen metabolism indexes were determined.Results:1 week and 2 weeks after treatment, serum LDH, CK, CK-MB, ET-1, Ang-II, PICP and PINP contents of both groups were significantly lower than those before treatment while SOD, GSH-Px, CAT and HO-1 contents were significantly higher than those before treatment and serum LDH, CK, CK-MB, ET-1, Ang-II, PICP and PINP contents of intervention group were significantly lower than those of control group while SOD, GSH-Px, CAT and HO-1 contents were significantly higher than those of control group.Conclusion: Adenosine cyclophosphate combined with vitamin C therapy for viral myocarditis can reduce myocardial injury and improve collagen metabolism.
