摘要
Objective: To study the correlation of the abnormal FoxM1 and Sox9 expression in osteosarcoma with the pathologic features of tumor. Methods: Patients with osteosarcoma and those with giant cell tumor who received surgical resection in Enshi Youfu hospital between March 2015 and August 2017 were selected and enrolled in the osteosarcoma group and control group of the study after the tissue properties were confirmed by pathological examination. The lesion tissue was collected after operation to determine the mRNA expression of FoxM1, Sox9, proliferation genes and invasion genes. Results: FoxM1, Sox9, AURKA, PAK5, IRX2, S100A6, FAK, MMP9, PIPK4 and N-cadherin mRNA expression in lesion tissue of osteosarcoma group were significantly higher than those of control group whereas Id1 and TAp73 mRNA expression were significantly lower than those of control group;AURKA, PAK5 and IRX2 mRNA expression in lesion tissue of osteosarcoma group with high FoxM1 expression were significantly higher than those in lesion tissue with low FoxM1 expression whereas Id1 and TAp73 mRNA expression were significantly lower than those in lesion tissue with low FoxM1 expression;S100A6, FAK, MMP9, PIPK4 and N-cadherin mRNA expression in lesion tissue of osteosarcoma group with high Sox9 expression was significantly higher than those in lesion tissue with low Sox9 expression. Conclusion: The abnormal high expression of FoxM1 and Sox9 in osteosarcoma can promote the cell proliferation and invasion within the tumor.
