摘要
Objective:To study the correlation between serum homocysteine (Hcy) content and the changes in patients with type 2 diabetic peripheral neuropathy (DPN).Methods: The patients who were diagnosed with T2DM between March 2015 and April 2018 in our hospital were chosen and divided into the DPN group combined with DPN and the T2DM group not combined with DPN;healthy volunteers were chosen as the control group. The serum contents of Hcy, folic acid (FA), vitamin B12 (VitB12), inflammation indexes and oxidation indexes as well as sensory nerve conduction velocity (SCV) in extremities were measured.Results:Serum Hcy, soluble vascular cell adhesion molecule-1 (sVCAM-1), interleukin-1β (IL-1β) and high mobility group B1 (HMGB1) contents of DPN group were significantly higher than those of T2DM group and control group while serum FA, VitB12, superoxide dismutase (SOD) and glutathione peroxidase (GSH) contents as well as median nerve, ulnar nerve, radial nerve, common peroneal nerve and tibial nerve SCV levels were significantly lower than those of T2DM group and control group;serum sVCAM-1, IL-1β and HMGB1 contents significantly increased while serum SOD and GSH contents as well as median nerve, ulnar nerve, radial nerve, common peroneal nerve and tibial nerve SCV levels significantly decreased in DPN group of patients with hyperhomocysteinemia.Conclusion: Serum Hcy content significantly increases in patients with DPN, and it can aggravate the nerve conduction function injury and activate the inflammatory and oxidative reaction.
