摘要
目的:分析恶性卵巢上皮性肿瘤(Malignant ovarian epithelial tumors)组织中cripto-1的表达情况及其与恶性卵巢上皮性肿瘤临床病理特征之间的关系。方法采用免疫组化技术检测50例的恶性卵巢上皮性肿瘤患者癌组织中的cripto-1表达情况,并分析其与临床病理特征间的关系。结果在50例标本中, cripto-1在癌组织中的表达显著高于正常卵巢组织(χ2=41.302,P<0.01);cripto-1的高表达分别与分化程度、TNM分期显著有关(P<0.01)。结论 cripto-1的高表达在恶性卵巢上皮性肿瘤的发生发展中发挥重要作用。
Objective To analysis the expression of cripto-1 in malignant epithelial ovarian tumor and the relationship between these clinical pathologicals.Methods Immunohistochemistry was used to detect the expression of cripto-1 in 50 cases of malignant epithelial ovarian cancer tumor tissue,and analyze its relationship with clinical pathological characteristics between.Results In 50 specimens,Cripto-1 expression in cancer tissues was significantly higher than that in normal ovarian tissue(χ2=41.302,P<0.01);the expression of Cripto-1 and dif erentiation,TNM stage were significantly related(P<0.01).Conclusion The high expression of Cripto-1 in the genesis and development of malignant epithelial ovarian tumor play an important role in the malignant epithelial ovarian tumor.
作者
陈琳
范钰
CHEN Lin;FAN Yu(Zhenjiang City First People's Hospital,Zhenjiang Jiangsu 212002,China)
