摘要
目的考察注射用头孢呋辛钠和缩宫素注射液配伍的稳定性。方法在20℃下8 h内考察注射用头孢呋辛钠和缩宫素注射液配伍后,其混合溶液的外观、pH及不溶性微粒变化,并用高效液相色谱法测定药物的含量。结果注射用头孢呋辛钠和缩宫素注射液配伍后,8 h内药物的含量、混合溶液pH、外观及不溶性微粒均无明显变化。结论注射用头孢呋辛钠和缩宫素注射液不存在理化性的配伍禁忌。
Objective To study the compatible stability of Cefuroxime Sodium for injection with oxytocin injection.Methods The change of appearance,PH value and indissoluble particle in the mixture within 8 h at 20℃were observed after Cefuroxime Sodium for injection being combined with Oxytocin injection.The contents of drugs were determined by HPLC.Results No significant change was found in content,pH value,appearance and indissoluble particle in 8h after Cefuroxime Sodium injection being combined with Oxytocin injection.Conclusion There is no physical and chemical compatibility taboo when Cefuroxime Sodium for injection is combined with Oxytocin injection.
作者
陈卫民
冯燕
CHEN Wei-min;FENG Yan(Department of Pharmacy,The First People's Hospital of Foshan City,Foshan 528000,Guangdong,China)
