摘要
目的研究我院2009~2012年抗生素使用情况与3种革兰阴性菌耐药率相关性。方法采用回顾性调查方法,对我院2009~2012年多种抗菌药物的用药频度与大肠埃希菌、肺炎克雷伯菌、鲍曼不动杆菌的耐药率进行相关性分析。结果头孢吡肟的DDDs与产ESBL的大肠埃希菌耐药率呈正相关,亚胺培南/西司他丁的DDDs与非产ESBL的大肠埃希菌耐药率呈正相关,头孢哌酮/舒巴坦的DDDs与非产ESBL的肺炎克雷伯菌耐药率呈正相关,头孢哌酮/舒巴坦和亚胺培南/西司他丁的DDDs与鲍曼不动杆菌呈正相关。结论部分抗菌药物的使用量与细菌耐药率有相关性。
Objective To study the use of antibiotics in our hospital in 2009-2012 with three kinds of cases of gram-negative bacteria resistant rate correlation.Methods A retrospective study of a variety of hospital 2009-2012 DDDs of antibiotics with Escherichia coli,Klebsiel a pneumoniae,Acinetobacter baumanni resistant rate correlation analysis.Results The resistance rates of E.coli and ESBL-producing DDDs cefepime was positively correlated with imipenem/West Division DDDs and non-ESBL-producing E.coli resistance rates his smal positive correlation,cefoperazone/DDDs and the rate of non-resistant Klebsiel a pneumoniae producing ESBL positive correlation sulbactam,cefoperazone/sulbactam and imipenem/cilastatin in DDDs and Acinetobacter baumanni were positively correlated.Conclusion The amount of antimicrobial agents and use some of the rate of bacterial resistance correlated.
作者
黄靓
陈涛
HUANG Liang;CHEN Tao(Department of pharmacy,The First Affiliated Hospital of Zhongshan University,Guangzhou 510080,Guangdong,China;Department of pharmacy,Huizhou Zhongda Huiya Hospital,Huizhou 516081,Guangdong,China)
关键词
抗生素
耐药率
相关性
Antibiotic
Resistance rate
Correlation
