摘要
目的观察COPD患者血清IL-6和C反应蛋白(CRP)在3年随访中的变化与预后的关系。方法61例处于COPD稳定期的患者,测定其呼吸功能、血清IL-6和CRP水平、6min步行距离和身体指数作为基线,每年同一时期测定相同指标,跟踪随访3年。结果3年后IL-6水平明显高于基线值的患者(<0.05)的6min步行距离实验表现明显变差(<0.05);而CRP水平变化不明显(跃0.05)。结论 IL-6水平与COPD患者的预后有明显的相关性。
Objective The purpose of this study was to examine the relation between the concentration of plasma CRP and IL-6 and the prognosis in COPD patients.Methods A cohort of 61 outpatient with stable COPD was evaluated at baseline.We evaluated interleukin-6(IL-6),-reactive protein(CRP),six-minutes walking distance(6MWD),and body mass index(BMI)at baseline and after three years.Results IL-6 increased significantly after 3 years compared to baseline measurements(<0.05)and was associated with worse 6MWD performance(<0.05).CRP mean values did not change(﹥0.05)pompared with baseline after 3 years.Conclusion These results indicate that The systemic inflammatory process,evaluated by IL-6,seems to be persistent,progressive and associated with mortality and worse physical performance in COPD patients.
作者
蔡晓聪
谢媛媛
张凌波
张仕富
CAI Xiao-cong;XIE Yuan-yuan;ZHANG Ling-bo;ZHANG Shi-fu(Department of Pulmonary,General Hospital of Chongqing Iron&Steel Co.Ltd,Chongqing 400081,China)
关键词
慢性阻塞性肺疾病
白介素-6
C反应蛋白
Chronic obstructive pulmonary disease
Interleukin-6
C reactive protein
