摘要
目的 探讨不同剂量的特拉唑嗪治疗输尿管碎石术后患者输尿管支架管相关症状的疗效.方法 选取输尿管碎石术后留置输尿管D-J管的患者100例,随机分成4组,各25例.对照组未予特殊干预,A组给予特拉唑嗪1mg,1次/d;B组给予特拉唑嗪2mg,1次/d;C组给予特拉唑嗪5mg,1次/d,疗程为术后4周.所有患者均在输尿管碎石术后第1周及第4周完成输尿管支架管症状调查表(USSQ).结果 与对照组比较,所有药物治疗组患者排尿症状、躯体疼痛症状、身体一般状况、工作能力情况、性生活情况平均评分均下降.与A组比较,B组、C组患者排尿症状、躯体疼痛症状、身体一般状况、工作能力情况、性生活情况评分均有明显改善,组间差异有统计学意义(P<0.05),而B组和C组比较,差异无统计学意义(P>0.05).结论 特拉唑嗪能够明显改善输尿管支架管相关症状,且2mg治疗效果最佳,明显提高患者的生活质量.随着剂量的增大,其临床疗效强度无明显差异.
Objective To investigate the effect of different doses of terazosin on stent-related symptoms in patients after ureteral lithotripsy.Methods 100 cases after ureterolotripsy were randomly divided into 4 groups,the control group(n=25)was not given special intervention,group A(n=25)was given trazosin 1mg,1 times/d,B group(n=25)was given trazosin 2mg,1/d,C group(n=25)was given trazosin,1 times,4 weeks after the operation.All patients completed the Ureteral Stent Symptom Questionnaire(USSQ)at week 1 and week 4 after ureteral lithotripsy.Results 1.Compared with the control group,the average scores of urination symptoms,somatic pain,general physical condition,working ability and sexual life were decreased in all the treatment groups.2.Compared with group A,group B was significantly improved by trazosin 2mg and C group treated with trazosin 5mg for urination,body pain,body general,work ability and sex life.The difference between groups was statistically significant(P<0.05),but there was no statistical difference between group B and group C(P>0.05).Conclusion Terazosin can significantly improve the symptoms of ureteral stent related symptoms and the quality of life of patients,2 mg treatment is the best.There is no significant difference in clinical efficacy with the increase of dose.
出处
《浙江临床医学》
2019年第1期54-55,共2页
Zhejiang Clinical Medical Journal
基金
杭州市卫生局项目(2014a06).
