摘要
类风湿关节炎(rheumatoid arthritis,RA)患者临床症状出现前的早期疾病发展阶段,机体在达到RA的疾病诊断标准之前,体内疾病发展已经开始.RA是一个全身性自身免疫性疾病,对病程早期自身免疫的认识显得尤为重要.类风湿因子(rheumatoid factor,RF)、 抗瓜氨酸肽抗体(an-tibodies to citrullinated protein antigen,ACPA)是目前最熟知及研究最多的RA相关自身抗体,然而疾病早期的自身免疫紊乱状态与多种因素相关:如遗传因素、 环境因素的影响,及其他系统免疫紊乱对早期自身免疫产生的影响(口腔黏膜或牙周组织、 肺黏膜、 肠道免疫失调).本文重点探讨未来可能发展为RA高危患者临床症状出现前的早期自身免疫,以对RA疾病早期病理过程有一定的认识,对RA的发展有进一步的了解.
In the early stage of disease development in patients with rheumatoid arthritis(RA)before clinical symptoms appearance,that is,before patients reach the diagnostic criteria for RA,the development of disease in vivo has begun.RA is a systemic autoimmune disease.It is very important to understand the autoimmunity in the early stage of the disease.Rheumatoid factor(RF),anti-citrullinated protein antigen(ACPA)are the most well-known and studied RA-related autoantibodies.However,early autoimmune disorders are related to many factors,such as genetic factors,environmental factors,and other systemic immune disorders(oral mucosa or periodontal tissue,pulmonary mucosa,intestinal immune disorders).This article focuses on the early autoimmunity of high-risk patients who may develop into RA in the future before the clinical symptoms appear,which has a certain understanding of the early pathological process of RA,and let us have a further understanding of the development of RA.
作者
王丹
刘静
袁国华
WANG Dan;LIU Jing;YUAN Guo-hua(Institute of Rheumatic Immunology,Affiliated Hospital of North Sichuan Medical College,Nanchong 637000,Sichuan,China)
出处
《中华临床免疫和变态反应杂志》
2019年第4期322-327,共6页
Chinese Journal of Allergy & Clinical Immunology
关键词
类风湿关节炎
临床前期
自身免疫
Rheumatoid arthritis
Preclinical stage
Autoimmunity
