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重复经颅磁刺激联合帕罗西汀对老年抑郁症患者认知功能及心理状态的影响

Effects of Repeated Transcranial Magnetic Stimulation Combined with Paroxetine on Cognitive Function and Psychological Status in Senile Patients with Depression
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摘要 目的探讨重复经颅磁刺激(rTMS)联合帕罗西汀治疗老年抑郁症患者的效果.方法选取2020年9月—2022年4月本院收治的老年抑郁症患者92例,按随机数字表法分为两组.对照组46例采用帕罗西汀治疗,观察组46例在此基础上采用rTMS治疗,均持续治疗8周.对比两组的临床疗效、认知功能、心理状态及不良反应发生情况.结果观察组的总有效率97.83%高于对照组的82.61%,治疗后的汉密尔顿抑郁量表评分低于对照组,各维度认知功能评分均高于对照组,组间差异有统计学意义(P<0.05).两组的不良反应发生率比较,差异无统计学意义(P>0.05).结论rTMS联合帕罗西汀治疗老年抑郁症的效果显著,能有效改善患者的认知功能与心理状态,且安全性高. Objective To investigate the efficacy of repeated transcranial magnetic stimulation(rTMS)combined with paroxetine in senile patients with depression.Methods 92 elderly patients with depression admitted to our hospital from September 2020 to April 2022 were selected and were divided into two groups according to random number table method.The control group of 46 cases was treated with paroxetine,and the observation group of 46 cases was treated with rTMS on this basis.Both groups were treated for 8 weeks.The clinical efficacy,cognitive function,psychological status and adverse reactions of the two groups were compared.Results The total effective rate of the observation group was 97.83%,which was higher than 82.61%of the control group,after treatment,the Hamilton depression scale score was lower than that of the control group,the cognitive function scores of all dimensions were higher than those in the control group,and the differences between the groups were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion rTMS combined with paroxetine has a significant effect in the treatment of senile depression,which can effectively improve the cognitive function and mental state of patients with high safety.
作者 刘见锋 LIU Jianfeng(Department of Psychiatry,Lanling County Mental Health Center,Linyi City,Shandong Province,Linyi Shandong,277700,China)
出处 《反射疗法与康复医学》 2022年第21期62-64,共3页 Reflexology And Rehabilitation Medicine
关键词 老年抑郁症 帕罗西汀 重复经颅磁刺激 认知功能 心理状态 Senile depression Paroxetine Repeated transcranial magnetic stimulation Cognitive function Psychological status
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