摘要
目的探究孟鲁司特钠联合酮替芬对咳嗽变异性哮喘患儿咳嗽症状及肺功能的影响.方法选择2021年4月—2023年3月我院收治的80例变异性哮喘患儿为研究对象,按随机数字表法将其分为对照组和观察组,各40例.对照组患者采用酮替芬治疗,观察组在对照组治疗的基础上采用孟鲁司特钠治疗,治疗持续10周.比较两组咳嗽症状、肺功能及不良反应.结果治疗前,两组患儿的咳嗽症状积分比较,差异无统计学意义(P﹥0.05).治疗后,观察组患儿白天及夜晚咳嗽症状积分分别为(1.32±0.32)分、(1.27±0.41)分,均低于对照组的(1.98±0.58)分、(1.86±0.45)分,组间差异有统计学意义(P﹤0.05).治疗前,两组患儿的肺功能相关指标比较,组间差异无统计学意义(P﹥0.05).治疗后,观察组患儿的第1秒用力呼气容积大于对照组,呼气峰值流速值、一秒率均高于对照组,组间差异有统计学意义(P﹤0.05).治疗后,两组患儿的不良反应发生率比较,差异无统计学意义(P﹥0.05).结论孟鲁司特钠联用酮替芬治疗咳嗽变异性哮喘患儿疗效十分显著,患儿的咳嗽症状以及肺功能指标得到明显改善且安全性较高.
Objective To investigate the effect of montelukast sodium combined with ketotifen on cough symptoms and lung function in children with cough variant asthma.Methods 80 children with variant asthma admitted to our hospital from April 2021 to March 2023 were selected as the research objects.According to the random number table method,they were divided into a control group and an observation group,with 40 cases in each group.The control group was treated with ketotifen,and the observation group was treated with montelukast sodium on the basis of the treatment of the control group,and the treatment lasted for 10 weeks.The cough symptoms,lung function and adverse reactions were compared between the two groups.Results Before treatment,there was no statistically significant difference in cough symptom score between the two groups(P﹥0.05).After treatment,the cough symptom scores during the day and night in the observation group were(1.32±0.32)points and(1.27±0.41)points,respectively,which were lower than(1.98±0.58)points and(1.86±0.45)points in the control group,the differences between the two groups were statistically significant(P﹤0.05).Before treatment,there was no significant difference in pulmonary function related indicators between the two groups(P﹥0.05).After treatment,the forced expiratory volume in the first second of the observation group was higher than that of the control group,and the peak expiratory flow rate and ratio in one second were higher than those of the control group,and the differences between the two groups were statistically significant(P﹤0.05).After treatment,there was no significant difference in the total incidence of adverse reactions between the two groups(P﹥0.05).Conclusion Montelukast sodium combined with ketotifen is effective in the treatment of children with cough variant asthma,and the cough symptoms and lung function indexes of children are significantly improved with high safety.
作者
丰常申
丁涛
FENG Changshen;DING Tao(Department of General Practice,Rizhao Donggang District Maternal and Child health Hospital,Rizhao Shandong,276800,China;Department of Gynecology and Obstetrics,Rizhao Donggang District Maternal and Child Health Hospital,Rizhao Shandong,276800,China)
出处
《反射疗法与康复医学》
2024年第1期100-102,共3页
Reflexology And Rehabilitation Medicine
关键词
咳嗽变异性哮喘
孟鲁司特钠
肺功能
酮替芬
咳嗽症状
Cough variant asthma
Montelukast sodium
Pulmonary function
Ketotifen
Symptoms of cough
